Therapeutic drug monitoring to personalize dosing of imatinib, sunitinib, and pazopanib: A mixed methods study on barriers and facilitators

Abstract Background Personalized dosing based on measurement of individual drug levels and adjusting the dose accordingly can improve efficacy and decrease unnecessary toxicity of oncological treatment. For imatinib, sunitinib, and pazopanib, this therapeutic drug monitoring (TDM)‐guided dosing is, however, not routinely used, despite accumulating evidence favoring individualized dosing. Therefore, we aimed to identify and quantify (potential) barriers and facilitators in TDM‐guided dosing for imatinib, sunitinib, and pazopanib. Methods We performed a mixed methods study among all stakeholders involved: patients, healthcare professionals (HCPs), pharmaceutical companies, and health insurance companies. During the first qualitative part of this study, we performed semi‐structured individual interviews and one focus group interview to identify all (potential) barriers and facilitators, and during the second quantitative part of this study, we used a web‐based survey to quantify these findings. The interviews addressed the six domains of the implementation of change model of Grol and Wensing: (1) the innovation itself; (2) the HCP; (3) the patient; (4) social context; (5) organizational context; and (6) finances, law, and governance. Results In the qualitative study, we interviewed 20 patients, 18 HCPs and 10 representatives of pharmaceutical and health insurance companies and identified 72 barriers and 90 facilitators. In the quantitative study, the survey was responded by 66 HCPs and 58 patients. Important barriers were on the domain of the HCP, such as a lack of experience with TDM (36.4%), on the domain of the patient, such as lack of awareness of TDM (39.7%), and the processing time for measurement and interpretation of the TDM result (40.9%) (organizational domain). Important facilitators were education of HCPs (95.5%), education of patients (87.9%) and facilitating an overview of when and where TDM measurements are being performed (86.4%). Conclusion We identified and quantified important barriers and facilitators for the implementation of TDM‐guided dosing for imatinib, sunitinib, and pazopanib. Based on our results, the implementation strategy should mainly focus on educating both HCPs and patients and on the organizational aspect of TDM.


| INTRODUCTION
Tyrosine kinase inhibitors (TKIs) are oral oncologic drugs that target tyrosine kinases and have become important in the modern anticancer treatment of solid tumors. 1,2However, their potential might benefit from dose individualization.
Currently, much attention is paid to personalized medicine in oncology, for example by investigating specific genes or mutations that can be targeted by specific drugs. 3owever, once the appropriate drug has been selected, little attention is paid to personalize and optimize the dosage.5][6][7] The actual TKI exposure can differ up to 10-fold between patients. 8][11][12][13] For an increasing amount of TKIs, thresholds for drug exposure have been defined, meaning a minimum target level for optimal treatment benefit and an upper limit for preventing unnecessary toxicity. 7,14The window between these thresholds is called the therapeutic window.It has been demonstrated that up to 52% of patients treated with TKIs have sub-or supratherapeutic exposure, risking decreased efficacy or unnecessary toxicity, respectively. 4,5,7,15 method to optimize the dosage is trough routinely measured drug concentrations in plasma and adjusting the dose accordingly, which is called therapeutic drug monitoring (TDM). 16A plasma trough concentration (C trough ) outside the prespecified therapeutic window will lead to dose adjustments with the aim to give each individual patient the most optimal exposure level.TDMguided dosing is routinely used to optimize the treatment of patients treated with, for example antibiotics, immunosuppressants, or anti-epileptic drugs. 17,180][21] However, for TKIs, TDM-guided dosing is less common, despite accumulating evidence.Most evidence of the benefits for TDM-guided dosing is available for imatinib, sunitinib, and pazopanib specifically.3][24] In a recent study, the percentage of patients with a drug exposure below target decreased from 70.4% to 39.6%, 44.3% to 14.3%, and 26.7% to 16.7% for imatinib, sunitinib, and pazopanib, respectively, using TDM-guided dosing. 25Therefore, TDM-guided dosing is considered appropriate and implementable for these three TKIs.Still, its routine use in clinical practice is limited. 7,26,27o gain insight why innovations that lead to better treatment outcomes are not implemented into clinical practice instantly, various theories and models are available, for example the implementation of change model by Grol and Wensing. 28The first steps in this model are to explore and quantify existing and potential barriers and facilitators in the implementation of an innovation, since these barriers may require different strategies in order to overcome them.In the implementation of innovations, multiple stakeholders are involved, and therefore, it is important to identify barriers and facilitators for all stakeholders.
Currently, studies on barriers and facilitators of TDMguided dosing for TKIs are lacking.Identification and quantification of these barriers and facilitators can be used to develop a tailored strategy for implementation of TDM-guided dosing. 28Therefore, we performed a mixed methods study among all stakeholders to identify and quantify existing and potential barriers and facilitators in the current use of TDM-guided dosing for patients with solid tumors treated with imatinib, sunitinib, and pazopanib, which may also serve as a model for other oral oncolytics.

| Study design
We used a mixed methods design.In order to identify (potential) barriers and facilitators in the implementation of TDM-guided dosing for TKIs, we performed a qualitative study using semi-structured individual interviews among all stakeholders involved and one focus group interview among patients.Next, we performed a quantitative study

Conclusion:
We identified and quantified important barriers and facilitators for the implementation of TDM-guided dosing for imatinib, sunitinib, and pazopanib.Based on our results, the implementation strategy should mainly focus on educating both HCPs and patients and on the organizational aspect of TDM.

K E Y W O R D S
barriers, facilitators, implementation, therapeutic drug monitoring, tyrosine kinase inhibitors using a web-based survey to quantify the findings from the interviews and to assess the importance of the identified barriers and facilitators.This study was performed in line with the Dutch Code of Conduct for Research Integrity and the Consolidated criteria for Reporting Qualitative studies (COREQ). 29The study protocols for both the interview study and survey were approved by the local Medical Ethics Committee of the Radboudumc in Nijmegen, the Netherlands (dossier number 2019-5631 and 2022-16,004, respectively).

| Qualitative interviews
Four groups of stakeholders were identified in the implementation of TDM-guided dosing: patients, healthcare professionals (HCPs; both medical oncologists and hospital pharmacists), pharmaceutical companies, and health insurance companies.Among them, we performed semistructured individual interviews and one focus group interview with patients.
Patients were included if they had solid tumors and were treated with imatinib, sunitinib, or pazopanib.Exclusion criterium was a lack of understanding of the Dutch language.Experience with TDM was not mandatory.Patients were invited for the interview via an email sent by the Dutch Patient Advocacy Groups.
HCPs with experience in treatment of patients with solid tumors with imatinib, sunitinib, or pazopanib were invited by email to participate in the interview.Experience with TDM was not mandatory.We invited HCPs from different types of hospitals (academic, teaching, and non-teaching hospitals; n = 11) distributed over four regions in the Netherlands (north, east, south, and west).
The two pharmaceutical companies that produce imatinib, sunitinib, and pazopanib are Novartis and Pfizer.Two representatives of each company were invited by email for an interview.Two representatives of four large health insurance companies in the Netherlands (CZ, VGZ, Menzis, and Achmea) were invited by email to participate in the interview as well.

| Quantitative research: Survey
To quantify the barriers and facilitators found, an electronic survey was performed among HCPs and patients in the Netherlands.
All Dutch medical oncologists and hospital pharmacists received a hyperlink to the questionnaire through the e-mail service of the Dutch Society of Medical Oncology and Dutch Association of Hospital Pharmacists, respectively.The introduction of the questionnaire requested all medical oncologists who treat patients with imatinib, sunitinib, and pazopanib and all hospital pharmacists who are known with TDM-guided dosing to fill in the questionnaire.A reminder to the questionnaire was sent four times.Completion of the questionnaire took approximately 20 min.
The survey among patients was performed only in patients with gastrointestinal stromal tumor (GIST) treated with imatinib, since these patients are more familiar with prolonged TKI treatment and more experienced with TDM.Patients with GIST who received active treatment with imatinib and had experience with TDM-guided dosing were invited to fill in the questionnaire via an email with a hyperlink to the questionnaire sent by the Dutch Patient Advocacy Group.A patient information sheet was attached to the email, explaining the goal of the study.Patients could open the questionnaire by clicking on the hyperlink attached to the email.A reminder to the questionnaire was sent once, and completion took approximately 15 min.6) finances, law, and governance. 30,31ccording to the COREQ criteria for qualitative research, interviews with patients and HCPs were performed until data saturation was reached, meaning that additional interviews do not lead to new information. 29This means that the number of interviews is open at the beginning of the study and is determined by the data collected.Due to the small number of health insurance companies and pharmaceutical companies involved in this project, representatives of all companies involved were interviewed.
All participants who responded to the invitation were contacted by telephone or email by one of the researchers for additional information.All participants received written information explaining the goal of the study and the process of the interview.All participants signed informed consent and gave permission for audiotaping the interviews.None of the researchers were involved in the treatment of the patients.
The interviews were structured as follows: First, participants were asked to describe their experience with TDM-guided dosing.Then, open-ending questions addressing one of the domains were asked.We explored barriers and facilitators in detail when they came up during the interview.If no new input came up, a new domain was introduced.The individual interviews were conducted by a trained researcher (KW).The focus group interview with patients was conducted by two trained researchers (KW and RH).
For the patients, before the interviews were conducted, basic patient characteristics were collected by means of a short questionnaire.This questionnaire included questions about age, sex, home setting, occupational status, treatment setting, and type of TKI treated with.

| Survey
The barriers and facilitators identified in the interviews were converted into a web-based questionnaire for HCPs and patients using Limesurvey (https:// manual.limes urvey.org).
For HCPs, the first part of the questionnaire consisted of nine questions about the HCPs personal characteristics (e.g., age and years of experience) and clinical setting.The second part of the questionnaire addressed the barriers and facilitators identified in the interviews and consisted of 81 theses, scored on a five-point Likert scale ("strongly agree," "agree," "neutral," "disagree," and "strongly disagree").The majority of questions were to be answered by both medical oncologists and hospital pharmacists and some questions were for medical oncologists or hospital pharmacists only.
For patients, electronic informed consent was necessary to start the actual questionnaire.After informed consent was provided, the first part of the questionnaire contained 13 questions about the patients' characteristics (e.g., age, gender, and education) and treatment with imatinib.The second part of the questionnaire consisted of 43 theses and scored similar to the questionnaire of HCPs.These were the barriers and facilitators that were either mentioned by patients during the interviews or were on the patient domain.Since this was not a validated questionnaire, it was pilot tested by six patients for clarity, understanding, and language, after which some minor changes were made.
At the end of the questionnaire, all survey participants could mention additional barriers and facilitators and state comments.

| Qualitative interviews
All interviews were audiotaped and transcribed literally in Microsoft Word afterwards.The transcripts were imported in Atlas.Ti (version 8.4.20 Atlas.Ti Scientific Software Development GmbH; Berlin, Germany) and analyzed using framework content analysis. 32The framework was based on the six domains of Grol and Wensing. 31irst, two trained researchers (KW and CT) independently coded all barriers and facilitators mentioned in the interviews.Discrepancies were discussed until consensus was reached.If no consensus was reached, a third researcher (RH) was consulted.Second, comparable descriptive codes were combined and redefined into specific subthemes.The subthemes were merged into the six broader domains of the model of Grol and Wensing using axial coding.

| Survey
The questionnaire data were gathered in Limesurvey and exported into IBM SPSS statistics for Windows, version 27.0 (IBM Corp., Armonk, NY, USA).We included questionnaires of which at least 50% of the questions were completed.We used descriptive statistics to describe characteristics of the HCPs and patients.For the 5-point Likert scale theses, we calculated the percentage of HCPs and patients that agreed with the theses by combining the answers "strongly agree" and "agree."We considered a barrier or facilitator to be important when more than onethird (33%) of the respondents (strongly) agreed.In case the survey yielded a high number of important barriers and facilitators, the 10 most important barriers and facilitators for both HCPs and patients were selected.

| Study population
Between September 2019 and February 2021, we performed 1 focus group interview (n = 12) and 8 individual interviews with patients, 18 individual interviews with HCPs (n = 9 medical oncologists, n = 9 hospital pharmacists), 2 interviews with 2 representatives from the pharmaceutical companies during each interview, and 4 interviews with a total of 6 representatives of Dutch health insurance companies.Data saturation was reached after interviewing 18/20 patients and 16/18 HCPs, respectively.Basic patient characteristics are summarized in Table 1.TDM-guided dosing was applied in 50% of the patients in the interviews.HCPs from 10 different hospitals participated in the interviews (see Table S1).
The HCP survey yielded a total of 74 responses, of which 66 (89%) were completed for at least 50% and were included in the analysis.Among the responders were 33 medical oncologists and 33 hospital pharmacists from 45 hospitals (out of a total of 57 hospitals, 79%).Characteristics and clinical setting of the HCPs are shown in Table 2.
The patient survey yielded 67 responses, of which 58 (87%) were completed for at least 50% and included in the analyses.Characteristics of the patients are shown in Table 3.

| Barriers and facilitators
In the interviews, we identified a total of 72 barriers and 90 facilitators in all 6 domains of the framework.Within each domain, we grouped the barriers and facilitators ).An overview of all barriers and facilitators is shown in Tables 4 and 5, respectively.Illustrative quotations from the interviews are shown in Figure S1.
The responses to the theses in the questionnaire for HCPs and patients are shown in Tables 2 and 3, respectively.The 10 barriers and 10 facilitators that yielded the highest percentage of agreement in HCPs are shown in Figure 1 and Figure 2, respectively.The important barriers and 10 facilitators with highest percentage of agreement in patients are shown in Figures 3 and 4, respectively.Results from both the interviews and the survey will be discussed further by domain.

| Domain: Innovation itself (TDM)
The majority of HCPs in the survey recognized benefits of TDM-guided dosing, such as the opportunity to individualize treatment (87.9%).Especially in fragile patients, TDMguided dosing enables a physician to start at a low dose and increase the dose carefully based on C trough levels (68.2%).Patients in the survey also responded that TDM can help determine whether they are treated with the right dose (77.6%) and that the effect of treatment increases (69.0%) and the side effects decrease (60.3%) with TDM.Health insurance companies and pharmaceutical companies acknowledged these benefits of TDM in the interviews as well.
Many HCPs (40.9%) stated that prospective studies proving the added value of TDM-guided dosing on treatment outcome, such as improved survival, are required before they would perform TDM-guided dosing in routine clinical practice.The HCPs in the interviews mentioned that they did believe that TDM-guided dosing could be of added value in specific cases, but that they were not convinced of the added value of performing TDM-guided dosing in all patients in routine care.HCPs, patients and the pharmaceutical companies, mentioned during the interviews that TDM-guided dosing has not been implemented in clinical guidelines and/or local protocols and that this could cause both lack of awareness of TDM-guided dosing, but also decrease the willingness of HCPs to perform TDM-guided dosing.However, this was not confirmed by the survey.All health insurance companies in the interviews believed it could facilitate TDM to prove that TDM is cost-effective.

| Domain: Healthcare professional
HCPs agreed that they lack experience with TDM-guided dosing with TKIs (36.4%).Furthermore, many medical oncologists are reluctant to decrease the dose in case of a high C trough and limited side effects (43.9%) and agreed that it can be difficult to translate a dose advice to clinical practice when the C trough does not correlate with clinical presentation and the dose advice does not seem appropriate (42.4%).In the interviews, some medical oncologists mentioned patients that had severe side effects but low C trough levels.As a result, the hospital pharmacist advised to increase the dose, though this was not feasible in clinical practice.Many HCPs (45.5%) seem to be unaware that TDM-guided dose adjustments within label are covered by health insurance companies.The patient survey revealed no relevant barriers on the HCP domain.
The HCP survey results also showed that implementation of TDM would be facilitated if pharmacology of TKIs is implemented in education of HCPs (95.5%).Both HCPs (90.9%) and patients (91.4%) in the survey stated that they should be adequately informed about the processing time of the TDM result.

| Domain: Patient
Both HCPs and patients in the survey responded that patients are not aware of the possibility of performing TDMguided dosing (78.8% and 39.7%, respectively) or of the possibility of performing blood sampling in a local hospital closer to home (60.6% and 50.0%, respectively).In order to reliably calculate a C trough level, it is important that the blood sample is taken after the time it takes to reach the maximum drug concentration (T max ).HCPs in the survey stated that patients often forget to adjust timing of TKI intake to ensure the blood sample is taken after T max (43.9%).This was not found in the patient survey (25.9%), however.HCPs reported that patients fear lack of efficacy of treatment (in case of a low C trough or in case of a dose reduction based on TDM) (63.6%) and that repetitive dose reductions due to TDM can be confusing for patients (43.9%).Patients in the survey also agreed that they fear lack of efficacy in case of a low C trough (56.9%) or a dose reduction (37.9%) and that dose reductions can be difficult (34.5%).During the interviews, patients mentioned that performing TDM causes awareness of low C trough levels.This is a positive thing whenever a dose increase is feasible.However, when a dose increase is not feasible, for example due to previous toxicity at a higher dose, patients are made aware of low C trough levels and potential suboptimal treatment.This can cause anxiety and stress.
According to both HCPs and patients, TDM-guided dosing can increase patients' involvement in-(60.6%and 63.8%, respectively) and satisfaction about their treatment (51.5% and 56.9%, respectively).The value of patient advocacy groups in creating awareness of TDM among patients is recognized by both HCPs (54.5%) and patients (82.8%).

| Domain: Social context
Implementation of TDM in a certain hospital can be enhanced by the implementation of TDM-guided dosing in surrounding hospitals (63.6%).In case of an external C trough measurement, interpretation of external TDM result and subsequent dose advice is the responsibility of the local hospital pharmacist and they should not be bypassed by the medical oncologist (90.9%).
None of the barriers identified in the interviews on the domain of social context were considered to be important by the survey respondents.

| Domain: Organizational context
Although many barriers were mentioned on the domain of the organizational context in the interviews (Table 3), this was not confirmed in the survey.HCPs in the survey did only agree that the result of the C trough measurement takes too long (40.9%).Currently, the processing time for the measurement and interpretation of the C trough result is about 1-2 weeks.
It would facilitate TDM if an overview would be available of when and where C trough measurements are being performed (86.4%).During the interviews, HCPs mentioned that this would allow them to adjust timing of blood samples in order to obtain results more quickly.Patients in the survey stated that they would prefer blood sampling well before the appointment with the medical oncologist, to ensure that the TDM result is available (84.5%). of the added value of TDM.Both the health insurance and pharmaceutical companies in the interviews believed that arranging financial compensation for TDM measurements would facilitate its implementation and that this would be more straightforward when TDM is implemented into clinical guidelines or in the drug label.No barriers or facilitators for law and governance were mentioned during the interviews.

| DISCUSSION
In this mixed methods study, we identified many important barriers and facilitators in the implementation of TDM-guided dosing for patients with solid tumors treated with imatinib, sunitinib, and pazopanib in routine clinical practice.Barriers and facilitators were present in all domains of the framework of Grol and Wensing and among all stakeholders. 30,31Important barriers were a lack of experience of HCPs with TDM, difficulties in translating a dose advice to clinical practice, a lack of awareness of TDM among patients and the processing time for the measurement and interpretation of the C trough result.Important facilitators were the implementation of pharmacology of TKIs in the education of HCPs, education of patients and to provide an overview of when and where C trough measurements are being performed.Knowledge of these barriers and facilitators can help to successfully implement TDM-guided dosing of all oral oncolytics.
HCPs are an important stakeholder in the implementation of TDM-guided dosing.Many of the identified barriers are the result of a lack of awareness and knowledge.HCPs in the survey agreed that they lack experience with TDM-guided dosing, though they did recognize the added value of TDM-guided dosing in selected cases, such as old fragile patients.However, they request further prospective evidence proving the clinical benefits of routine TDM-guided dosing.In relation to this request, medical oncologists are reluctant to perform dose reductions in case of a high C trough and limited side effects.However, it is questionable whether a prospective randomized controlled trial studying the efficacy of TDM-guided dosing is feasible since TDMguided dosing is already part of routine practice in an F I G U R E 2 Ten facilitators with highest percentage of agreement for HCPs.C trough , trough concentration; HCP, healthcare professional; TDM, therapeutic drug monitoring; TKI, tyrosine kinase inhibitor.

F I G U R E 1
Ten barriers with highest percentage of agreement for HCPs.C trough , trough concentration; HCP, healthcare professional; TDM, therapeutic drug monitoring; TKI, tyrosine kinase inhibitor.increasing number of hospitals.HCPs are also not fully aware of the actual costs of analysis of (external) blood samples and of reimbursement of TDM-guided dose adjustments within label.In conclusion, education of HCPs on TDM could be an important tool to overcome many of these beforementioned barriers.The advantage of educating HCPs in the implementation of a healthcare innovation has been described in previous literature, for example concerning the implementation of TDM-guided dosing of vancomycin.The appropriateness of vancomycin dosing increased from 51% to 78% after an education-based intervention. 33,34However, little evidence is available regarding the optimal education strategies 34,35 and these may differ between HCP groups, such as pharmacists, physicians, or nurses. 36uring the interviews, it was suggested that knowledge of TDM-guided dosing could be increased by incorporating TDM into training programs of HCPs, especially of medical oncologists, since hospital pharmacists are well known with the concept of TDM-guided dosing due to their experience with other types of drugs. 17,18This latter statement could not be confirmed in the survey however, since 48.5% and 24.2% of hospital pharmacists and medical oncologists, respectively, considered themselves as having a lack of experience with TDM for TKIs.Therefore, TDM-guided dosing should be incorporated into education of all HCPs.
Survey results showed many barriers in the domain of the patients.These barriers are related to a lack of knowledge and awareness of the possibilities of TDMguided dosing and fears, such as fear of a lack of efficacy in case of a low C trough .Lack of knowledge in patients and a negative attitude of patients are well known as barriers for implementing optimal healthcare in literature. 37,38To overcome these barriers, survey results suggested patients can be informed properly about TDM-guided dosing either by their treating physician or via patient advocacy groups.Therefore, patients should be informed about TDM primarily by their medical oncologist and patient advocacy groups should cooperate with medical oncologists to provide correct and nuanced information.
An important barrier in the domain of organizational context was the duration of processing time for the measurement and interpretation of the C trough result.In most hospitals, no bioanalytical method to quantify TKI plasma concentrations is available.Therefore, it requires time to send the blood sample to another hospital, to analyze and interpret the result, to report the result back to the referring hospital and to interpret it there.This turnaround time from sample collection to reporting of the result could be reduced by providing an overview of when and where C trough measurements are being performed, as suggested in the survey.Furthermore, as stated by patients, blood samples should be obtained well ahead of the appointment with the medical oncologist.
Finally, in the finances, law, and governance domain, survey respondents suggested to arrange separate financial compensation for the analyses of TKIs.However, HCPs estimated the analytical costs of TDM measurement to be higher than the actual low prices, especially in regard to total costs of treatment (e.g., costs of the TKI, scans, and hospital visits).It has been demonstrated for imatinib that TDM-guided dosing is cost-effective in treating patients with GIST. 39With the (upcoming) loss of patency for some TKIs, cost-effectiveness will even be improved. 39his study has several strengths.First, we identified barriers and facilitators in all six domains of the theoretical framework of Grol and Wensing and interviewed all stakeholders involved.We included HCPs and patients until data saturation was reached and focused the interview guide on TKIs for which TDM-guided dosing has shown to be of added value and feasible in clinical practice.Therefore, we consider our data to be complete and specific.By conducting a nationwide survey among both HCPs and patients, we were able to quantitatively determine the most important barriers and facilitators in order to determine an implementation strategy.Furthermore, by using this framework, we are able to translate our findings to all oral oncolytics with scientific support for TDMguided dosing, since they are not specific for the three drugs involved.
This study has some limitations as well.First, we were not able to calculate a survey response rate because of privacy regulations of the Dutch Society of Medical Oncology and the Dutch Association of Hospital Pharmacists.However, the coverage of hospitals that treat patients with solid tumors with imatinib, sunitinib, and pazopanib in the survey was 79% and especially hospitals that treat a large number of patients were represented in the survey.Second, due to the differences in health care systems and the application of TDM-guided dosing in other countries, it might be difficult to extrapolate part of our results to other countries.On the contrary, themes such as awareness, knowledge, and education may be considered to play a role more universally.
In conclusion, we identified and quantified barriers and facilitators enabling a successful strategy to implement TDM-guided dosing of oral oncolytics for patients with solid tumors.We would recommend to focus this strategy on educating both HCPs and patients and to reduce turnaround time from sample collection to reporting of results.
to the Netherlands Cancer Institute.W.G. has received institutional research fees from Lilly and advisory compensation from Springworks, PTC Therapeutics and Agenus all to the institute.
N.E.received grants for the conduct of investigator driven studies from Ipsen and Astellas.
The other authors declare no conflict of interest.

2. 3 |
Data collection 2.3.1 | Qualitative interviews All interviews were performed with an interview guide based on the theoretical model of Grol and Wensing and addressed the six domains of this model: (1) the innovation itself; (2) the HCP; (3) the patient; (4) the social context; (5) the organizational context; and (

T A B L E 1
Abbreviations: TDM, therapeutic drug monitoring; TKI, tyrosine kinase inhibitor.a Two patients failed to return the questionnaire; therefore, some information is missing.b Low educational level: primary education, lower general secondary education, preparatory secondary vocational education; intermediate educational level: secondary vocational education, higher general secondary education, pre-university education; high educational level: higher vocational education, academic education.

F I G U R E 3
Important barriers for patients.TDM, therapeutic drug monitoring.F I G U R E 4Ten facilitators with highest percentage of agreement for patients.TDM, therapeutic drug monitoring.
Baseline characteristics healthcare professionals survey.
T A B L E 2Abbreviation: TDM, therapeutic drug monitoring.
Baseline characteristics patients survey.
T A B L E 3 Barriers interviews.Facilitators interviews.
T A B L E 4financial compensation for costs of TDM measurements (86.4%), by incorporating TDM in the drug label by the pharmaceutical companies (83.3%) or by incorporating it as a quality requirement by health insurance companies (83.3%).However, 87.9% of HCPs agreed that concerns of HCPs about costs could be overcome by convincing themT A B L E 5Abbreviations: C trough , trough concentration; CYP3A4, Cytochrome P450 3A4; HCP, healthcare professional; TDM, therapeutic drug monitoring; TKI, tyrosine kinase inhibitor.